{"id":1659,"date":"2021-02-08T11:58:29","date_gmt":"2021-02-08T19:58:29","guid":{"rendered":"http:\/\/mydiabeticsoul.com\/?p=1659"},"modified":"2021-02-08T11:58:29","modified_gmt":"2021-02-08T19:58:29","slug":"7-stem-cellar-report","status":"publish","type":"post","link":"http:\/\/mydiabeticsoul.com\/?p=1659","title":{"rendered":"#7…”Stem Cellar” Report"},"content":{"rendered":"\n\n\n
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New post on The Stem Cellar<\/strong><\/h2>\n<\/td>\n

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Month of CIRM: Reviewing\u00a0Review<\/a><\/h2>\n

by Kevin McCormack<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Dr. Gil Sambrano, Vice President Portfolio & Review<\/figcaption><\/figure>\n<\/div>\n

All this month we are using our blog and social media to highlight a new chapter in CIRM\u2019s life, thanks to the voters approving Proposition 14<\/a>. We are looking back at what we have done since we were created in 2004, and also looking forward to the future.<\/em> Today we take a look at our Review team.<\/em><\/p>\n

Many people who have to drive every day don\u2019t really think about what\u2019s going on under the hood of their car. As long as the engine works and gets them from A to B, they\u2019re happy. I think the same is true about CIRM\u2019s Review team. Many people don\u2019t really think about all the moving parts that go into reviewing a promising new stem cell therapy.<\/p>\n

But that\u2019s a shame, because they are really missing out on watching a truly impressive engine at work.<\/p>\n

Just consider the simple fact that since CIRM started about 4,000 companies, groups and individuals have applied to us for funding. Just take a moment to consider that number. Four thousand. Then consider that at no time have there been more than 5 people working in the review team. That\u2019s right. Just 5 people. And more recently there have been substantially fewer. That\u2019s a lot of projects and not a lot of people to review them. So how do they do it? Easy. They\u2019re brilliant.<\/p>\n

First, as applications come in they are scrutinized to make sure they meet specific eligibility requirements; do they involve stem cells, is the application complete, is it the right stage of research, is the budget they are proposing appropriate for the work they want to do etc. If they pass that initial appraisal, they then move on to the second round, the Grants Working Group or GWG.<\/p>\n

The GWG consists of independent scientific experts from all over the US, all over the world in fact. However, none are from California because we want to ensure there are no possible conflicts of interest. When I say experts, I do mean experts. These are among the top in their field and are highly sought after to do reviews with the National Institutes of Health etc.<\/p>\n

Mark Noble, PhD, the Director of the Stem Cell and Regenerative Medicine Institute at the University of Rochester, is a long-time member of the GWG. He says it\u2019s a unique group of people:<\/p>\n

\u201cIt\u2019s a wonderful scientific education because you come to these meetings and someone is putting in a grant on diabetes and someone\u2019s putting in a\u00a0 grant on repairing the damage to the heart or spinal cord injury or they have a device that will allow you to transplant cells better and there are people\u00a0 in the room that are able to talk knowledgeably about each of these areas and understand how this plays into medicine and how it might work in terms of actual financial development and how it might work in the corporate sphere and how it fits in to unmet medical needs . I don\u2019t know of any comparable review panels like this that have such a broad remit and bring together such a breadth of expertise which means that every review panel you come to you are getting a scientific education on all these different areas, which is great.\u201d<\/p>\n

The GWG reviews the projects for scientific merit: does the proposal seem plausible, does the team proposing it have the experience and expertise to do the work etc. The reviewers put in a lot of work ahead of time, not just reviewing the application, but looking at previous studies to see if the new application has evidence to support what this team hope to do, to compare it to other efforts in the same field. There are disagreements, but also a huge amount of respect for each other.<\/p>\n

Once the GWG makes its recommendations on which projects to fund and which ones not to, the applications move to the CIRM Board, which has the final say on all funding decisions. The Board is given detailed summaries of each project, along with the recommendations of the GWG and our own CIRM Review team. But the Board is not told the identity of any of the applicants, those are kept secret to avoid even the appearance of any conflict of interest.<\/p>\n

The Board is not required to follow the recommendations of the GWG, though they usually do. But the Board is also able to fund projects that the GWG didn\u2019t place in the top tier of applications. They have done this on several occasions, often when the application targeted a disease or disorder that wasn\u2019t currently part of the agency\u2019s portfolio.<\/p>\n

So that\u2019s how Review works. The team, led by Dr. Gil Sambrano, does extraordinary work with little fanfare or fuss. But without them CIRM would be a far less effective agency.<\/p>\n

The passage of Proposition 14 means we now have a chance to resume full funding of research, which means our Review team is going to be busier than ever. They have already started making changes to the application requirements. To help let researchers know what those changes are we are holding a Zoom webinar tomorrow, Thursday, at noon PST. If you would like to watch you can find it on our YouTube channel<\/a>. And if you have questions you would like to ask send them to info@cirm.ca.gov<\/a> <\/em><\/p>\n

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Kevin McCormack<\/a><\/strong> | January 6, 2021 at 10:54 am | Tags: CIRM Board<\/a>, Dr. Gil Sambrano<\/a>, Grants working group<\/a>, Mark Noble<\/a>, National Institutes of Health<\/a>, NIH<\/a>, Review<\/a>, University of Rochester Stem Cell and Regenerative Medicine Institute<\/a> | Categories: Basic Research<\/a>, California Institute for Regenerative Medicine<\/a>, CIRM Board<\/a>, CIRM funded research<\/a>, Discovery Research<\/a>, ICOC Board Meetings<\/a>, Month of CIRM<\/a>, Month of CIRM<\/a>, National Institutes of Health<\/a>, Stem cell research<\/a>, Translational research<\/a> | URL: https:\/\/wp.me\/p4BBpx-4HH<\/a><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

New post on The Stem Cellar Month of CIRM: Reviewing\u00a0Review by Kevin McCormack Dr. Gil Sambrano, Vice President Portfolio & Review All this month we are using our blog and social media to highlight a new chapter in CIRM\u2019s life, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1659","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/posts\/1659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1659"}],"version-history":[{"count":1,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/posts\/1659\/revisions"}],"predecessor-version":[{"id":1660,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=\/wp\/v2\/posts\/1659\/revisions\/1660"}],"wp:attachment":[{"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1659"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/mydiabeticsoul.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}